СИНТЕЗ КЕРАМИЧЕСКИХ МАТЕРИАЛОВ НА ОСНОВЕ КАРБИДА ТИТАНА С КОБАЛЬТОВОЙ СВЯЗКОЙ ДЛЯ ИМПУЛЬСНОГО ЭЛЕКТРОИСКРОВОГО ОСАЖДЕНИЯ БИОАКТИВНЫХ ПОКРЫТИЙ С АНТИБАКТЕРИАЛЬНЫМ ЭФФЕКТОМ

Целью данной работы являлось получение биосовместимых керамических материалов в системе Ti–C–Co–Ca₃(PO₄)₂– Ag–Mg синтезом в режиме горения. Изучено влияние кобальта на параметры горения смеси, структуру и свойства получаемых продуктов. Компактная керамика состоит из связанного каркаса зерен нестехиометрического карбида титана (TiC_0,5–TiC_0,6) с равномерно распределенной по границам зерен фазой фосфата титана (Ti₃PO_x) и локальными выделениями оксида кальция (CaO). При введении кобальта образуются комплексный фосфид CoTiP и интерметаллид TiCo. Легирование серебром и магнием приводит к формированию твердого раствора на основе серебра.

1. Mishnaevsky L.Jr., Levashov E., Valiev R.Z., Segurado J., Sabirov I., Enikeev N., Prokoshkin S., Solov’yov A.V., Korotitskiy A., Gutmanas E., Gotman I., Rabkin E., Psakh’e S., Dluhoš L., Seefeldt M., Smolin A. Nanostructured titanium-based materials for medical implants: Mode-ling and development. Mater. Sci. Eng. R. 2014. Vol. 81. P. 1—19.

2. Carlos Nelson Eliasa, Daniel Jogaib Fernandes, Celso R.S. Resende, Jochen Roestel. Mechanical properties, surface morphology andstability of a modified commercially pure highstrength titanium alloy for dental implants. Dental Materials. 2015. Vol. 31. Iss. 2. P. e1—e13.

3. Naddeo P., Laino L., La Noce M., Piattelli A., De Rosa A., Iezzi G., Lainod G., Painoa F., Papaccio G., Tirino V. Surface biocompatibility of differently textured titanium implants with mesenchymal stem cells. Dental Materials. 2015. Vol. 31. Iss. 3. P. 235—243.

4. Bosco R., Edreira E.R.U., Wolke J.G., Leeuwenburgh S.C., van den Beucken, J.J., Jansen J.A. Instructive coatings for biological guidance of bone implants. Surf. Coat. Technol. 2013. Vol. 233. P. 91—98.

5. Cloutier M., Mantovani D., Rosei F. Special focus on materials: Review. Antibacterial coatings: Challenges, perspectives and opportunities. Trends Biotechnol. 2015. Vol. 33. P. 637—652.

6. Gitlevich A.E., Mikhailov V.V., Parkanskii N.Ya., Revutskii V.M. Elektroiskrovoe legirovanie metallicheskikh poverkhnostei [Electrospark alloying of metallic surfaces]. Ed. Yu.I. Petrov. Kishinev: Shtiintsa, 1985.

7. Nikaido T., Tsuru K., Munar M., Maruta M., Matsuya S., Nakamura S., Ishikawa K. Fabrication of β-TCP foam: Effects of magnesium oxide as phase stabilizer on its properties. Ceram. Int. 2015. Vol. 41. P. 14245—14250.

8. Engin N.Ö., Taş A.C. Preparation of porous Ca10(PO4)6(OH)2 and β-Ca3(PO4)2 bioceramics. J. Am. Ceram. Soc. 2000. Vol. 83. P. 1581—1584.

9. Surmenev R.A., Surmeneva M.A., Ivanova A.A. Significance of calcium phosphate coatings for the enhancement of new bone osteogenesis: Review. Acta Biomater. 2014. Vol. 10. P. 557—579.

10. Zhang B.G., Myers D.E., Wallace G.G., Brandt M., Choong, P.F. Bioactive coatings for orthopaedic implants — recent trends in development of implant coatings. Int. J. Molecular Sci. 2014. Vol. 15. P. 11878—11921.

11. Mahdieh Bashoor-Zadeh, Gamal Baroud, Marc Bohner. Simulation of the in vivo resorption rate of β-tricalcium phosphate bone graft substitutes implanted in a sheep model. Biomaterials. 2011. Vol. 32. P. 6362—6373.

12. Levashov E.A., Rogachev A.S., Epishko Yu.K., Kochetov N.A. Self propagating high-temperature synthesis of target cathodes in the system Ti—Ta—C—Ca3(PO4)2 for the ion-plasma deposition of multifunctional tissue-compatible nanostructured coatings. Rus. J. Non-Ferr. Met. 2007. Vol. 48. P. 496—506.

13. Potanin A.Yu., Levashov E.A., Pogozhev Yu.S., Shvindina N.V., Kovalev D.Yu. The features of combustion and structure formation of ceramic materials in the TiC— Ti3POx—CaO system. Ceram. Int. 2015. Vol. 41. Iss. 6. P. 8177—8185.

14. Loginov P.A., Levashov E.A., Potanin A.Yu., Kudryashov A.E., Manakova O.S., Shvyndina N.V., Sukhorukova I.V. Sintered Ti—Ti3P—CaO electrodes and their application for pulsed electrospark treatment of titanium. Ceram. Int. 2016. Vol. 42. Iss. 6. P. 7043—7053.

15. Levashov E.A., Rogachev A.S., Kurbatkina V.V., Maksimov Yu.M., Yukhvid V.I. Perspektivnye materialy i tekhnologii samorasprostranyayushchegosya vysokotemperaturnogo sinteza [Advanced materials and technology SHS]. Moscow: Izd. dom MISIS, 2011.

16. Yeh C.L., Yeh C.C. Preparation of CoTi intermetallics by self-propagating combustion synthesis. J. Alloys Compd. 2005. Vol. 396. P. 228—232.

17. Kamynina O.K., Gotman I., Gutmanas E., Sytschev A.E., Vadchenko S.G., Balikhina E.N. Combustion synthesis of porous Ti—Co alloys for orthopedic applications. Int. J. SHS. 2009. Vol. 18. P. 102—108.

18. Sytschev A.E., Kamynina O.K., Umarov L.M., Shchu-kin A.S., Vadchenko S.G. Porous Ti—Co alloys and their joining with titanium by SHS cladding. Int. J. SHS. 2015. Vol. 24. P. 171—173.

19. Sychev A.E., Kamynina O.K., Umarov L.M., Schukin A.S., Zhidkov M.V. SHS of composite materials based on Ti— Co. Mod. Probl. Sci. Educ. 2014. Vol. 12. P. 1912—1916.

20. Sytschev A.E., Vadchenko S.G., Kamynina O.K., Balikhina E.N., Plashchina I.G., Krylova E.A., Grigor’yan A.S., Toporkova A.K., Konovalov A.N., Selezneva I.I. Porous materials from titanium—cobalt alloys for hybrid implants. Cell Technol. Biol. Med. 2009. Vol. 1. P. 160—165.

21. Simchi A., Tamjid E., Pishbin F., Boccaccini A.R. Recent progress in inorganic and composite coatings with bactericidal capability for orthopaedic applications. Nanomed.: Nanotechnol., Biol. Medicine. 2011. Vol. 7. P. 22—39.

22. Reyes-Vidal Y., Suarez-Rojas R., Ruiz C., Torres J., Stefan Talu, Alia Méndez, Trejo G. Electrodeposition, characterization, and antibacterial activity ofzinc/silver particle composite coatings. Appl. Surf. Sci. 2015. Vol. 342. P. 34—41.

23. Stevens K.N.J., Crespo-Biel O., van den Bosch E.E., Di-as A.A., Knetsch M.L., Aldenhoff Y.B., van der Veen F.H., Maessen J.G., Stobberingh E.E., Koole L.H. The relationship between the antimicrobial effect of catheter coatings containing silver nanoparticles and the coagulation of contacting blood. Biomaterials. 2009. Vol. 30. P. 3682— 3690.

24. Chena W., Liu Y., Courtney H.S., Bettenga M., Agrawal C.M., Bumgardner J.D., Ong J.L. In vitro anti-bacterial and biological properties of magnetron co-sputtered silver-containing hydroxyapatite coating. Biomaterials. 2006. Vol. 27. P. 5512—5517.

25. Shtansky D.V., Batenina I.V., Kiryukhantsev-Korneev Ph.V., Sheveyko A.N., Kuptsov K.A., Zhitnyak I.Y., Anisimova N.Yu., Gloushankova N.A. Ag- and Cu-doped multi-functional bioactive nanostructured TiCaPCON films. Appl. Surf. Sci. 2013. Vol. 285. P. 331—343.

26. Mróz W., Bombalska A., Burdynska S., Jedynski M., Prokopiuk A., Budner B., Slósarczyk A., Zima A., Menaszek E., Scisłowska-Czarnecka A., Niedzielski K. Structural studies of magnesium doped hydroxyapatite coatings after osteoblast culture. J. Mol. Struct. 2010. Vol. 977. P. 145—152.

27. Danielle Laurencin, Neyvis Almora-Barrios, Nora H. de Leeuw, Christel Gervais, Christian Bonhomme, Francesco Mauri, Wojciech Chrzanowski, Jonathan C. Knowles, Robert J. Newport, Alan Wong, Zhehong Gan, Mark E. Smith. Magnesium incorporation into hydroxyapatite. Biomate-rials. 2011. Vol. 32 P. 1826—1837

28. Webster T.J., Massa-Schueter E.A., Smith J.L., Slamovich E.B. Osteoblast response to hydroxyapatite doped with divalent and trivalent cations. Biomaterials. 2004. Vol. 25. P. 2111—2121.

29. Zueva L.V., Gusev A.I. Effect of nonstoichiometry and ordering on the period of the basis structure of cubic titanium carbide. Phys. Solid State. 1999. Vol. 41. P. 1032—1038.

30. Murray J.L. The Co—Ti (cobalt—titanium) system. Bull. Alloy Phase Diagr. 1982. Vol. 3. P. 74—85.

31. Gorelik S.S., Skakov Yu.A., Rastorguev L.N. Rentgenograficheskii i elektronno-opticheskii analiz [X-ray and electron-optical analysis]. Moscow: Izd. dom MISIS, 1994.

32. Nayeb-Hashemi A.A., Clark J.B. The Ag—Mg (silver— magnesium) system. Bull. Alloy Phase Diagr. 1984. Vol. 5. P. 348—358.

33. Drits M.E., Budberg P.B., Burkhanov G.S., Drits A.M., Pa-novko V.M. Svoistva elementov [Properties of the elements]. Moscow: Metallurgiya, 1985.

34. Kiparisov S.S., Levinsky Yu.V., Petrov A.P. Karbid titana: poluchenie, svoistva, primenenie [Titanium carbide: production, properties and application]. Moscow: Metallurgiya, 1987.

35. Ziemnicka-Sylwester M. TiB2-based composites for ultra-high-temperature devices, fabricated by SHS, combining strong and weak exothermic reactions. Materials. 2013. Vol. 6. P. 1903—1919.